Heat a skillet over medium heat.
Add the ground beef and finely chopped onion to the skillet.
Cook the beef and onion, breaking the meat apart with a spoon, until fully browned and cooked through.
Season the mixture with Worcestershire sauce, salt, black pepper, garlic powder, and onion powder if using.
Cook for another 1 to 2 minutes until fragrant and well combined.
Split the slider buns horizontally.
Spoon warm seasoned beef onto the bottom half of each bun, leaving it loose to keep it juicy.
Add optional toppings such as mustard, pickles, cheese slices, diced onions, or ketchup as desired.
Place the top bun on each slider and serve immediately while hot.