In a bowl, mix ground beef with garlic powder, smoked paprika, onion powder, salt, and pepper until just combined.
Divide the mixture into 12 equal portions and form each into a patty slightly wider than the buns.
Heat a skillet or grill over medium-high heat.
Cook patties 3 to 4 minutes per side until cooked through and edges are slightly charred.
During the last minute, brush patties with BBQ sauce and top with cheese slices if desired to melt.
Split and lightly toast slider buns using a toaster, oven, or skillet.
Spread BBQ sauce on the bottom halves of buns.
Assemble sliders by placing patties on buns, then add crispy onions, pickle slices, and optional lettuce or tomato.
Place the top buns on sliders and secure each with a toothpick or small skewer.
Serve sliders warm with extra BBQ sauce for dipping.